![](/CAS/GIF/5980-97-2.gif)
2,4,6-Trimethylphenylboronic acid synthesis
- Product Name:2,4,6-Trimethylphenylboronic acid
- CAS Number:5980-97-2
- Molecular formula:C9H13BO2
- Molecular Weight:164.01
![Trimethyl borate](/CAS/GIF/121-43-7.gif)
121-43-7
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$14.00/25mL
![2,4,6-Trimethybromombenzene](/CAS/GIF/576-83-0.gif)
576-83-0
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$27.00/25G
![2,4,6-Trimethylphenylboronic acid](/CAS/GIF/5980-97-2.gif)
5980-97-2
254 suppliers
$10.00/1g
Yield:5980-97-2 85%
Reaction Conditions:
Stage #1: 2,4,6-trimethylphenyl bromidewith magnesium in tetrahydrofuran; for 3 h;Reflux;
Stage #2: Trimethyl borate in tetrahydrofuran at -78 - 20; for 12 h;
Steps:
General procedure of boronic acid synthesis
General procedure: A solution of 1 equiv. (10 mmol) mesitylbromide and 5 ml THF was addeddropwise to 1.2 equiv. (12 mmol, 0.30g) activated Mg turnings in 10 ml THF.After the reaction started, the mixture was refluxed for 3 hours. Then the reactionmixture was cooled to -78°C, and treated with 2 equiv. (20 mmol, 2.0g) offreshly distilled trimethylborate, and then the reaction mixture was allowed to warm up toroom temperature, and stirred overnight (12 hours). The reaction was quenched with 2 equiv.(20 mmol, 20 ml) 1M HCl-solution at 0 °C, then the mixture was stirred at rt. for two hours.The phases were separated and the aqueous phase was washed with 3x10 ml diethyl ether.The combined organic layer was washed with brine three times, dried over anhydrousNa2SO4, filtered off and evaporated to dryness. The resulted solid/oil was suspended in hexane,filtered off, washed with hexane 3 times and dried.
References:
Dorkó, éva;Kótai, Bianka;F?ldes, Tamás;Gy?m?re, ádám;Pápai, Imre;Soós, Tibor [Journal of Organometallic Chemistry,2017,vol. 847,p. 258 - 262] Location in patent:supporting information
![2,4,6-Trimethybromombenzene](/CAS/GIF/576-83-0.gif)
576-83-0
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$27.00/25G
![2,4,6-Trimethylphenylboronic acid](/CAS/GIF/5980-97-2.gif)
5980-97-2
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$10.00/1g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
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![BORANE-DIISOPROPYLAMINE](/CAS/20211123/GIF/55124-35-1.gif)
55124-35-1
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$60.00/100mg
![2,4,6-Trimethybromombenzene](/CAS/GIF/576-83-0.gif)
576-83-0
247 suppliers
$27.00/25G
![2,4,6-Trimethylphenylboronic acid](/CAS/GIF/5980-97-2.gif)
5980-97-2
254 suppliers
$10.00/1g
![Trimethyl borate](/CAS/GIF/121-43-7.gif)
121-43-7
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$14.00/25mL
![Water](/CAS/GIF/7732-18-5.gif)
7732-18-5
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$13.50/100ML
![2,4,6-TRIMETHYLPHENYLMAGNESIUM BROMIDE](/CAS/GIF/2633-66-1.gif)
2633-66-1
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$91.00/100ml
![2,4,6-Trimethylphenylboronic acid](/CAS/GIF/5980-97-2.gif)
5980-97-2
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$10.00/1g
![2.4.6-Methyltrimethylbenzeneborate](/CAS/20180808/GIF/34907-53-4.gif)
34907-53-4
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![2,4,6-Trimethylphenylboronic acid](/CAS/GIF/5980-97-2.gif)
5980-97-2
254 suppliers
$10.00/1g