2,4,7-trichloro-6-fluoro-quinazoline synthesis
- Product Name:2,4,7-trichloro-6-fluoro-quinazoline
- CAS Number:174566-16-6
- Molecular formula:C8H2Cl3FN2
- Molecular Weight:251.47
174565-49-2
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Yield:174566-16-6 1.45 g (82%)
Reaction Conditions:
in ice-water;trichlorophosphate;
Steps:
10.b 8-Chloro-9-fluoro-2,3,5,6-tetrahydro-1,2,4-triazolo[4,3-c]quinazoline-3,5-dione
b) 1.5 g (0.0070 mol) of 7-chloro-6-fluoro-1,2,3,4-tetrahydroquinazoline-2,4-dione were suspended in 9.6 ml (0.10 mol) of phosphorus oxychloride and heated to 105° C. for 84 hrs. The reaction mixture was left to cool to room temperature and poured on to ice-water. The brown precipitate was extracted with dichloromethane and chromatographed over silica gel with dichloromethane as the eluent. Yield: 1.45 g (82%) of 2,4,7-trichloro-6-fluoro-quinazoline as yellowish crystals; m.p. 90°-92° C.
References:
US5688803,1997,A
108288-16-0
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