2-(4-acetylphenoxy)-2-methylpropionic acid synthesis
- Product Name:2-(4-acetylphenoxy)-2-methylpropionic acid
- CAS Number:52179-07-4
- Molecular formula:C12H14O4
- Molecular Weight:222.24
2052-01-9
266 suppliers
$10.00/1g
99-93-4
861 suppliers
$5.00/25g
52179-07-4
6 suppliers
$501.45/5MG
Yield:52179-07-4 65%
Reaction Conditions:
with potassium carbonate in ethanol; pH=7; for 13 h;Reflux;
Steps:
Synthesis of 2-(4-acetyl-2-substituted phenoxy)-2-methyl propanoic acid (2)
In 500 ml of RBF, provide with reflux condenser placed 4-hydroxyacetophenone (0.01 mol), 2-bromo-2-methyl propanoic acid (0.01 mol) and K2CO3 (0.03 mol) in 25 ml of distilled ethanol. Then resultant solution was refluxed in water bath. After 1 h, pH of the solution had dropped to 7, and further 1 g of K2CO3 was added. Refluxing was continued for a 12 h. The hot solution was acidified with concd HCl. The product was extracted with diethyl ether. Ether layer was washed with 50 ml of saturated solution of Sodium Bicarbonate. The aqueous layer was acidified with dil HCl acid. White colored solid was filtered off, washed with water dried and recrystallized by hot water to get the desired compounds (2). Mp 102 °C, % yield 65%.
References:
Mokale, Santosh N.;Elgire;Sakle, Nikhil;Shinde, Devanand B. [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 2,p. 682 - 685] Location in patent:experimental part
99-93-4
861 suppliers
$5.00/25g
52179-07-4
6 suppliers
$501.45/5MG