![](/CAS/GIF/94205-62-6.gif)
2-(4-AMINO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID synthesis
- Product Name:2-(4-AMINO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID
- CAS Number:94205-62-6
- Molecular formula:C16H12N2O2
- Molecular Weight:264.28
![Isatin](/CAS/GIF/91-56-5.gif)
91-56-5
440 suppliers
$5.00/25g
![4-Aminoacetophenone](/CAS/GIF/99-92-3.gif)
99-92-3
507 suppliers
$6.00/10g
![2-(4-AMINO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID](/CAS/GIF/94205-62-6.gif)
94205-62-6
28 suppliers
$85.00/250mg
Yield:94205-62-6 99%
Reaction Conditions:
with water;potassium hydroxide in ethanol at 100;
Steps:
33.A.1 Step 1: 2-(4-aminophenyl)quinoline-4-carboxylic acid
[00442] A solution of 1 -(4-aminophenyl)ethan- 1 -one (27.5 g, 104 mmol) in EtOH (200 mL) was added to a solution of indoline-2,3-dione (20 g, 148 mmol) in 6 M aqueous KOH (200 mL) at 100°C. The reaction was monitored by LC-MS until the starting material was consumed. Then the reaction mixture was concentrated to remove EtOH. The residue was diluted with water. The pH value of the mixture was acidified to 5 by adding 1M aqueous HC1 solution. The precipitate was filtered to give the desired product (28 g, 99%) as red solid.
References:
WO2017/184547,2017,A1 Location in patent:Paragraph 00363; 00442