2-(4-AMinophenyl)isothiazolidine 1,1-dioxide synthesis

3synthesis methods

Product Name:2-(4-AMinophenyl)isothiazolidine 1,1-dioxide
CAS Number:90556-91-5
Molecular formula:C9H12N2O2S
Molecular Weight:212.27

2-(4-nitrophenyl)isothiazolidine 1,1-dioxide

90868-48-7
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2-(4-AMinophenyl)isothiazolidine 1,1-dioxide

90556-91-5
27 suppliers
$45.00/100mg

Yield:90556-91-5 91.3%

Reaction Conditions:

with palladium on activated charcoal;hydrogen in methanol;dichloromethane; for 16 h;

Steps:

1.2 Step2) 4-(1,1-dioxo-1,2-thiazolidin-2-yl)aniline

A solution of 2-(4-nitrophenyl)-1,2-thiazolidine 1,1-dioxide (400.0 mg, 1.65 mmol, 1 eq) in MeOH (3 mL)/DCM (2 mL) was hydrogenated in the presence of Pd/C (100.0 mg) at 35 °C and 50 psi for 16 h. The mixture was filtered. The filtrate was concentrated under reduced pressure to give the title compound (320 mg, yield: 91.3%) as an off-white solid. MS obsd. ESI MS [M+H]⁺: 213

References:

WO2021/249893,2021,A1 Location in patent:Page/Page column 46-47

350-46-9 Synthesis

350-46-9
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90556-91-5
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$45.00/100mg

References

636-98-6
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$17.00/5g

90556-91-5
27 suppliers
$45.00/100mg

References