2,4-bis(4-bromophenyl)-6-chloro-1,3,5-triazine synthesis
- Product Name:2,4-bis(4-bromophenyl)-6-chloro-1,3,5-triazine
- CAS Number:754980-62-6
- Molecular formula:C15H8Br2ClN3
- Molecular Weight:425.51
Yield:754980-62-6 80.5 g
Reaction Conditions:
Stage #1: 1.4-dibromobenzenewith n-butyllithium in diethyl ether;hexane at -70; for 3 h;Inert atmosphere;
Stage #2: 1,3,5-trichloro-2,4,6-triazine in diethyl ether;hexane at -70; for 2 h;
Steps:
A flask was charged with 1,4-dibromobenzene (200 g, 0.85 mol) and diethyl ether (1.5 L). The solution was cooled to <-70 °C under nitrogen and a solution of n-butyllithium in hexane (305 mL, 2.5 M, 0.764 mol) was added dropwise and the solution was stirred for 3 h.A separate flask was charged with cyanuric chloride (70.4 g, 0.38 mol) and diethyl ether (500 mL). The solution was cooled to 99% HPLC). 1H-NMR (400 MHz, CDC13): δ [ppm] δ 7.71 (d, J = 8.8 Hz, 4H), 8.49 (d, J = 8.8 Hz, 4H).
References:
WO2017/103586,2017,A1 Location in patent:Page/Page column 32-34
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