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2,4-bis(benzyloxy)-5-isopropenylbenzoic acid synthesis
- Product Name:2,4-bis(benzyloxy)-5-isopropenylbenzoic acid
- CAS Number:912545-09-6
- Molecular formula:C24H22O4
- Molecular Weight:374.43
![methyl 2,4-bis-benzyloxy-5-isopropenylbenzoate](/CAS/20180703/GIF/912545-08-5.gif)
912545-08-5
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![2,4-bis(benzyloxy)-5-isopropenylbenzoic acid](/CAS/20180703/GIF/912545-09-6.gif)
912545-09-6
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Yield:912545-09-6 100%
Reaction Conditions:
Stage #1: 2,4-bis-benzyloxy-5-isopropenyl-benzoic acid methyl esterwith potassium hydroxide;water in methanol; for 16 h;Heating / reflux;
Stage #2: with hydrogenchloride in water; pH=<= 2;Product distribution / selectivity;
Steps:
1.6
Potassium hydroxide (10.96 g, 0.19 mmol) was added to a stirred suspension of methyl 2,4-bis-benzyloxy-5-isopropenyl-benzoate (61.0 g, 0.16 mol) in methanol (750 ml) and water (250 ml) and the mixture was stirred and held at reflux for 16 hours. Upon cooling the organic solvent was removed in vacuo and the mixture acidified to pH 2 or below by the addition of 2M hydrochloric acid (200 ml). The mixture was diluted with water (2 L) and extracted with ethyl acetate (2 L), the organic layer was separated and the solvent removed in vacuo to afford 2,4-bis-benzyloxy-5-isopropenyl-benzoic acid (58.8 g, 100%) as a colourless solid. 1H NMR (DMSO-d6) 7.52 (2H, d), 7.47-7.29 (9H, m), 6.82 (1 H, s), 5.20 (2H, s), 5.17 (2H, s), 5.06 (1 H, s), 5.04 (1 H, s), 2.03 (3H, s). MS: [M+H]+ 375.
References:
WO2008/44034,2008,A1 Location in patent:Page/Page column 93
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912545-07-4
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![2,4-bis-benzyloxy-5-isopropenyl-benzoic acid benzyl ester](/CAS/20180703/GIF/912545-15-4.gif)
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![Benzyl bromide](/CAS/GIF/100-39-0.gif)
100-39-0
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$10.00/10g
![2,4-bis(benzyloxy)-5-isopropenylbenzoic acid](/CAS/20180703/GIF/912545-09-6.gif)
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![Methyl 2,4-dihydroxybenzoate](/CAS/GIF/2150-47-2.gif)
2150-47-2
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$7.00/5g
![2,4-bis(benzyloxy)-5-isopropenylbenzoic acid](/CAS/20180703/GIF/912545-09-6.gif)
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