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ChemicalBook CAS DataBase List 2(4'-BROMOPHENYL)-2',4',6'-TRIHYDROXYACETOPHENONE

2(4'-BROMOPHENYL)-2',4',6'-TRIHYDROXYACETOPHENONE synthesis

2synthesis methods
Obtained by reaction of 4-bro-mophenylacetonitrile with phloroglucinol (Hoesch reaction).
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Yield:147220-80-2 54%

Reaction Conditions:

Stage #1: 3,5-dihydroxyphenol;4-Bromophenylacetonitrilewith zinc(II) chloride in diethyl ether at 0;
Stage #2: with hydrogenchloride in diethyl ether;

References:

Ren, Yuyan;Chen, Hongfei;Yao, Xu;Yang, Zehua;Wu, Tingjuan;Guo, Yu;Xiao, Junhui;Zheng, Xing [Pharmaceutical Chemistry Journal,2020,vol. 54,# 9,p. 924 - 931]