2(4'-BROMOPHENYL)-2',4',6'-TRIHYDROXYACETOPHENONE synthesis
2synthesis methods
- Product Name:2(4'-BROMOPHENYL)-2',4',6'-TRIHYDROXYACETOPHENONE
- CAS Number:147220-80-2
- Molecular formula:C14H11BrO4
- Molecular Weight:323.14
Obtained by reaction of 4-bro-mophenylacetonitrile with phloroglucinol (Hoesch reaction).
Yield:147220-80-2 54%
Reaction Conditions:
Stage #1: 3,5-dihydroxyphenol;4-Bromophenylacetonitrilewith zinc(II) chloride in diethyl ether at 0;
Stage #2: with hydrogenchloride in diethyl ether;
References:
Ren, Yuyan;Chen, Hongfei;Yao, Xu;Yang, Zehua;Wu, Tingjuan;Guo, Yu;Xiao, Junhui;Zheng, Xing [Pharmaceutical Chemistry Journal,2020,vol. 54,# 9,p. 924 - 931]