ChemicalBook CAS DataBase List 2-(4-BROMOPHENYL)FURAN

2-(4-BROMOPHENYL)FURAN synthesis

13synthesis methods

Product Name:2-(4-BROMOPHENYL)FURAN
CAS Number:14297-34-8
Molecular formula:C10H7BrO
Molecular Weight:223.07

13331-23-2 Synthesis

13331-23-2
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589-87-7 Synthesis

589-87-7
531 suppliers
$10.00/1g

14297-34-8
29 suppliers
$68.00/250mg

Yield:14297-34-8 94%

Reaction Conditions:

with tetrabutylammomium bromide;sodium carbonate;triphenylphosphine;palladium 10% on activated carbon in tetrahydrofuran;water at 60;

Steps:

A.1

Preparation of intermediate 1 A lO L vessel under N₂ was charged with 4-bromoiodobenzene (301 g; 1,06 moles), 2-furanboronic acid (148.81 g; 1,25 moles), triphenylphosphine (13.95 g; 0.05 moles), tetra-n-butylammonium bromide (377.29 g; 1.1 moles), sodium carbonate (225.53 g; 2 moles), palladium on carbon 10% (60.20 g; 56.57 mmoles), tetrahydrofuran (3.72 L) and water (3.72 L). The reaction mixture was heated at 60 ⁰C for 20 until gas chromatography showed no unreacted starting material. After cooling to room temperature, the reaction mixture was filtered over decalite. The organic layer was separated and washed with a saturated NaCl solution (2 L), concentrated under reduced pressure and diluted with toluene (1.5 L). The solids which formed were filtered off and washed with toluene (1 L). The combined toluene layers were concentrated and purified by column chromatography (silica gel; hexane). The product was crystallized from ethano I/water (2.27 L / 2.27 L) and dried. Yield: 266 g of intermediate 1 (2-(4- bromophenyl)-furan) (94%).

References:

WO2008/40669,2008,A2 Location in patent:Page/Page column 7

13331-23-2 Synthesis

13331-23-2
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$13.43/250mgs:

106-37-6 Synthesis