2-([(4-BROMOPHENYL)METHYL]AMINO)ACETAMIDE synthesis
1synthesis methods
- Product Name:2-([(4-BROMOPHENYL)METHYL]AMINO)ACETAMIDE
- CAS Number:850859-09-5
- Molecular formula:C9H11BrN2O
- Molecular Weight:243.1004
Yield:850859-09-5 92 g
Reaction Conditions:
Stage #1: glycinamide hydrochloride;4-bromo-benzaldehydewith sodium hydroxide in methanol;water at 20; for 17 h;
Stage #2: with sodium tetrahydroborate in methanol;water at 0;
References:
Van Der Stelt, Mario;Cals, Jos;Broeders-Josten, Silvia;Cottney, Jean;Van Der Doelen, Antoon A.;Hermkens, Marcel;De Kimpe, Vera;King, Angela;Klomp, Jan;Oosterom, Julia;Pols-De Rooij, Ilse;De Roos, Jeroen;Van Tilborg, Martin;Boyce, Susan;Baker, James [Journal of Medicinal Chemistry,2011,vol. 54,# 20,p. 7350 - 7362] Location in patent:experimental part