[2-(4-CHLORO-PHENYL)-OXAZOL-4-YL]-METHANOL synthesis
- Product Name:[2-(4-CHLORO-PHENYL)-OXAZOL-4-YL]-METHANOL
- CAS Number:22087-22-5
- Molecular formula:C10H8ClNO2
- Molecular Weight:209.63
22091-36-7
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22087-22-5
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Yield:22087-22-5 85%
Reaction Conditions:
with sodium hydroxide in sodium hydroxide; for 3 h;
Steps:
30.A
Example 30A [2-(4-Chlorophenyl)-1,3-oxazol-4-yl]methanol 6 g (26.307 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole were heated under reflux in 526 ml (52.613 mmol) of 0.1 N aqueous sodium hydroxide solution for 3 h. The mixture was then cooled to room temperature, and the precipitated solid was filtered off, washed with 0.1N aqueous sodium hydroxide solution and dried under high vacuum. This gave 4.79 g (85% of theory) of the target compound. LC-MS (Method 4): Rt=0.94 min; MS (ESIpos): m/z=210 [M+H]+.
References:
US2011/136871,2011,A1 Location in patent:Page/Page column 27
300800-07-1
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22087-22-5
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104-88-1
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619-56-7
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22087-22-5
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