2-(4-CHLOROANILINO)-4(3H)-QUINAZOLINONE synthesis

9synthesis methods

Product Name:2-(4-CHLOROANILINO)-4(3H)-QUINAZOLINONE
CAS Number:60420-44-2
Molecular formula:C14H10ClN3O
Molecular Weight:271.7

13463-94-0
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134-20-3 Synthesis

134-20-3
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60420-44-2
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Yield:60420-44-2 95%

Reaction Conditions:

Stage #1: N-(4-chlorophenyl)cyanamide;2-carbomethoxyanilinewith chloro-trimethyl-silane in tert-butyl alcohol at 60; for 4 h;
Stage #2: with sodium hydroxide in ethanol;water;tert-butyl alcohol; for 6 h;Reflux;regioselective reaction;

References:

Liao, Zhen-Yuan;Yeh, Wen-Hsiung;Liao, Pen-Yuan;Liu, Yu-Ting;Chen, Ying-Cheng;Chen, Yi-Hung;Hsieh, Tsung-Han;Lin, Chia-Chi;Lu, Ming-Hsuan;Chen, Yi-Song;Hsu, Ming-Chih;Li, Tsai-Kun;Chien, Tun-Cheng [Organic and Biomolecular Chemistry,2018,vol. 16,# 24,p. 4482 - 4494] Location in patent:supporting information

607-69-2 Synthesis