2-(4-Chlorophenyl)benzonitrile synthesis
- Product Name:2-(4-Chlorophenyl)benzonitrile
- CAS Number:89346-58-7
- Molecular formula:C13H8ClN
- Molecular Weight:213.66
Yield:89346-58-7 98%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);potassium carbonate in 1,4-dioxane;water at 90;
Steps:
1 Example 1
Add 2-iodobenzonitrile (5g, 21.8mmol), (4-chlorophenyl) boronic acid (4.08g, 26.16mmol), K2CO3 (12.03g, 87.2mmol), and tetrakis (triphenylphosphine) palladium Pd (PPh3) 4 (254 mg, 0.22 mmol) was dissolved in a mixture of 1,4-dioxane and water (200 ml, 1,4-dioxane / water = 10/1, v / v). The resulting solution was heated at 90 ° C overnight. After cooling to room temperature, the solution was mixed with 200 mL of water and the desired product was extracted with dichloromethane. The organic layer was collected and evaporated under reduced pressure. The crude product obtained was purified by column chromatography using petroleum ether / dichloromethane (PE / DCM, 3/1, V / V) as the eluent.4'-Chloro-[1,1'-biphenyl]-2-carbonitrile was obtained as a white solid (4.57 g, 98%).and the results of the 1H-NMR test are shown in FIG. 1.
References:
CN110452155,2019,A Location in patent:Paragraph 0053-0055
