2,4-DIBROMOPYRIMIDINE synthesis
- Product Name:2,4-DIBROMOPYRIMIDINE
- CAS Number:3921-01-5
- Molecular formula:C4H2Br2N2
- Molecular Weight:237.88
66-22-8
765 suppliers
$5.00/10g
3921-01-5
128 suppliers
$26.00/250mg
Yield: 78.5%
Reaction Conditions:
with phosphorus(V) oxybromide at 125; for 2 h;Temperature;Concentration;
Steps:
1.1 Example 1 The first step: 2,4-dibromopyrimidine synthesis
A mixture of phosphorus oxybromide (40.13 g, 0.14 mol) and uracil (3 g, 0.027 mol) was stirred at 125 ° C for 2 hours. The reaction was allowed to cool to room temperature and the reaction mixture was slowly poured into 500 g of ice water and washed with solid sodium bicarbonate Neutralization reaction. The aqueous phase is extracted twice with 150 ml of methylene chloride. The organic phase was dried and dried under reduced pressure to give 6.2 g of crude product,The crude product was then purified on a flash silica gel column to give 5 g of a white solid (yield: 78.5%).
References:
Shanghai Zaiqi Biological Co., Ltd.;Wang Zhiguo;Song Yanhong;Ma Xiujuan;Tian Beibei;Li Shijiang;Li Chao;Li Qiang;Li Tao CN106632077, 2017, A Location in patent:Paragraph 0017; 0018; 0019; 0025; 0026; 0027; 0032-0034
4595-60-2
357 suppliers
$8.00/5g
3921-01-5
128 suppliers
$26.00/250mg
3934-20-1
707 suppliers
$9.00/1g
3921-01-5
128 suppliers
$26.00/250mg