2,4-dichloro-3-isocyanato-1,5-dimethoxybenzene synthesis
- Product Name:2,4-dichloro-3-isocyanato-1,5-dimethoxybenzene
- CAS Number:872511-32-5
- Molecular formula:C9H7Cl2NO3
- Molecular Weight:248.06
872509-56-3
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Yield:872511-32-5 80%
Reaction Conditions:
with triethylamine in 1,4-dioxane at 130; for 2 h;Microwave irradiation;
Steps:
100.d; 2A d. 2, 4-Dichloro-3-isocyanafo-l, 5-dimethoxy-benzene
d. 2, 4-Dichloro-3-isocyanafo-l, 5-dimethoxy-benzene A mixture of 2,6-dichioro- 3,5-dimethoxy-phenylamine (500 mg, 2.25 mmol), triphosgene (335 mg, 1.12 mmol) and TEA (342 mg, 3.38 mmol) in dioxane (15 mL) was heated to 130 °C for 2 hours under microwave. The reaction was concentrated and the residue was purified by flash chromatography on silica eiuting with DCM to obtain the title compound (450 mg, yield: 80%). 1H-NMR (400 MHz, CDC13) δ 3.92 (s, 6H), 6.42 (s, 1H).
References:
WO2015/57938,2015,A1 Location in patent:Page/Page column 36
943189-21-7
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79257-61-7
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872511-32-5
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