ChemicalBook CAS DataBase List 2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine

2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine synthesis

5synthesis methods

Product Name:2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine
CAS Number:74901-71-6
Molecular formula:C6H4Cl2N2S
Molecular Weight:207.08

5719-34-6 Synthesis

5,7-Dihydrothieno[3,4-d]pyrimidine-2,4-diol

5719-34-6
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2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine

74901-71-6
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Yield:74901-71-6 1.6 g

Reaction Conditions:

with P,P-dichlorophenylphosphine oxide at 135 - 165;

Steps:

1; 1.v

Step (v)To thieno[3,4-d]pyrimidine-2,4-(lH, 3H, 5H, 7H)-dione (1.6 g, 9.41 mmol) was suspended in 4.0 mL of phenylphosphonyl dichloride and the suspension heated overnight at 135 °C, then for 1 hour at 165 °C. The resulting reaction mixture was cooled down and poured into ice-water. The aqueous layer was extracted with ethyl acetate. The organic layers were combined, washed with saturated NaHC0₃ solution and brine, dried over anhydrous Na₂S0₄ and evaporated. The crude product was then purified by column chromatography on silica gel (eluent: PE/EA=20/1-10/1) to give 2,4-dichloro-5,7-dihydrothieno[3,4-d]pyrimidine as a light yellow solid(l .6 g, 83%).LC-MS (Method A), (ES+)207/ 209, RT = 4.96 min.

References:

WO2013/50508,2013,A1 Location in patent:Page/Page column 42; 56

5719-34-6 Synthesis

5719-34-6
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74901-71-6
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$175.00/100mg

References

7400-45-5
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74901-71-6
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References

2689-68-1 Synthesis

Methyl 4-oxotetrahydrothiophene-3-carboxylate

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74901-71-6
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References

Thieno[3,4-d]pyrimidin-4(3H)-one, 2-(ethylthio)-5,7-dihydro-

5719-20-0
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74901-71-6
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References