2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine synthesis
- Product Name:2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine
- CAS Number:74901-71-6
- Molecular formula:C6H4Cl2N2S
- Molecular Weight:207.08
![5,7-Dihydrothieno[3,4-d]pyrimidine-2,4-diol](/CAS/GIF/5719-34-6.gif)
5719-34-6
16 suppliers
inquiry
74901-71-6
52 suppliers
$175.00/100mg
Yield:74901-71-6 1.6 g
Reaction Conditions:
with P,P-dichlorophenylphosphine oxide at 135 - 165;
Steps:
1; 1.v
Step (v)To thieno[3,4-d]pyrimidine-2,4-(lH, 3H, 5H, 7H)-dione (1.6 g, 9.41 mmol) was suspended in 4.0 mL of phenylphosphonyl dichloride and the suspension heated overnight at 135 °C, then for 1 hour at 165 °C. The resulting reaction mixture was cooled down and poured into ice-water. The aqueous layer was extracted with ethyl acetate. The organic layers were combined, washed with saturated NaHC03 solution and brine, dried over anhydrous Na2S04 and evaporated. The crude product was then purified by column chromatography on silica gel (eluent: PE/EA=20/1-10/1) to give 2,4-dichloro-5,7-dihydrothieno[3,4-d]pyrimidine as a light yellow solid(l .6 g, 83%).LC-MS (Method A), (ES+)207/ 209, RT = 4.96 min.
References:
WO2013/50508,2013,A1 Location in patent:Page/Page column 42; 56
5719-34-6
16 suppliers
inquiry
74901-71-6
52 suppliers
$175.00/100mg
7400-45-5
63 suppliers
$41.00/1g
74901-71-6
52 suppliers
$175.00/100mg
2689-68-1
133 suppliers
$20.00/250mg
74901-71-6
52 suppliers
$175.00/100mg
![Thieno[3,4-d]pyrimidin-4(3H)-one, 2-(ethylthio)-5,7-dihydro-](/CAS/20210111/GIF/5719-20-0.gif)
5719-20-0
1 suppliers
inquiry
74901-71-6
52 suppliers
$175.00/100mg