ChemicalBook CAS DataBase List 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE

2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE synthesis

3synthesis methods

Product Name:2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE
CAS Number:1053228-29-7
Molecular formula:C6H2Cl2FN3
Molecular Weight:206

90213-66-4
481 suppliers
$8.00/250mg

2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE

1053228-29-7
63 suppliers
$174.00/100mg

Yield: 80.1%

Reaction Conditions:

with acetic acid;Selectfluor in acetonitrile at 80; for 24 h;

Steps:

82.1 Step 1: Preparation of 2,4-dicMoro-5-fluoro-7H^yrrolo[2,3-d]pyrimidine
After 2,4-dicMoro-7H-pyrrolo[2,3-d]pyrimidine (200 mg, 1.06 mmol) was dissolved in acetonitrile (5.0 mL), l-chloromethyl-4-fluoro-l,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (561.6 mg, 1.6 mmol) and acetic acid (1 mL) were added thereto. The mixture was heated at 80 °C and stirred for 24 hours, and then the organic layer was isolated, treated with magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was isolated by column chromatography to obtain a title compound (170.0 mg, yield: 80.1%). (0795) NMR (500MHz,CD₃OD) δ 7.36(s, 1H)

References:

DAEWOONG PHARMACEUTICAL CO., LTD.;KIM, In Woo;HAN, Mi Ryeong;YOO, Jakyung;OH, Yun Ju;KIM, Ji Duck;KIM, Nam Youn;JUN, Sun Ah;LEE, Jun Hee;PARK, Joon Seok WO2018/4306, 2018, A1 Location in patent:Page/Page column 91

90213-66-4
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$8.00/250mg

1053228-29-7
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$174.00/100mg

1053228-28-6 Synthesis

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine

1053228-28-6
83 suppliers
$28.00/100mg

References

39929-79-8 Synthesis

39929-79-8
193 suppliers
$8.00/250mg

1053228-29-7
63 suppliers
$174.00/100mg

References