2,4-Dichloro-6-(methylamino)-1,3,5-triazine synthesis
- Product Name:2,4-Dichloro-6-(methylamino)-1,3,5-triazine
- CAS Number:27282-80-0
- Molecular formula:C4H4Cl2N4
- Molecular Weight:179.01
Yield:27282-80-0 97%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in tetrahydrofuran at -70 - 20; for 3 h;
Steps:
Cyanuric chloride (10 g, 54.3 mmol, 1 equiv. ) was dissolved in THF (200 mL) and cooled TO-70 °C. DIISOPROPYLETHYLAMINE (DIPEA) (36.3 mL, 1.42 mmol, 2 equiv. ) and METHYLAMINE hydrochloride (3.7g, 1 equiv. ) were added to the reaction mixture, which was stirred 2HO0 AT-70 °C and lh at room temperature. The THF was removed in vacuo and the remaining material was taken up in DCM and washed with water. The organic layer was dried with MGS04 and the DCM removed to give a colourless powder (9. 5g, 97%) MS (ESI+) : 181.2 ; MS (ESI-) : 179.2.
References:
WO2004/98607,2004,A1 Location in patent:Page/Page column 45
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