ChemicalBook CAS DataBase List 2,4-Dichloro-7-fluoroquinazoline

2,4-Dichloro-7-fluoroquinazoline synthesis

4synthesis methods

Product Name:2,4-Dichloro-7-fluoroquinazoline
CAS Number:174566-15-5
Molecular formula:C8H3Cl2FN2
Molecular Weight:217.03

76088-98-7 Synthesis

76088-98-7
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$45.00/50mg

174566-15-5
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Yield: 78%

Reaction Conditions:

with trichlorophosphate for 72 h;Heating / reflux;

Steps:

100
A suspensionof 7-fluoro-2, 4-dioxo(1H, 3X) quinazoline (Method 98,1. 8 g, 10 mmol) inPOC13 (30 ml) was heated under reflux for 72 hours. The brown coloured solution was concentrated to dryness under vacuum. The residue was treated with ice water (50 ml) and filtered. The residue was washed with ice-cold water (10 ml) and dried to give the desired product(1. 7 g, 78%). 1H NMR(CDC13)5 7.92(m,1 H), 7.95 (d, J = 2.9 Hz, 1 H), 8.42(m,1 H). MS: m/z 219 (M+3), 217(M+1).

References:

ASTRAZENECA AB;ASTRAZENECA UK LIMITED WO2005/49033, 2005, A1 Location in patent:Page/Page column 113

76088-98-7 Synthesis

76088-98-7
80 suppliers
$45.00/50mg

174566-15-5
136 suppliers
$25.00/100mg

References

32315-10-9 Synthesis