ChemicalBook CAS DataBase List 2,4-Dichloropyrido[3,2-d]pyrimidine

2,4-Dichloropyrido[3,2-d]pyrimidine synthesis

7synthesis methods

Product Name:2,4-Dichloropyrido[3,2-d]pyrimidine
CAS Number:39551-54-7
Molecular formula:C7H3Cl2N3
Molecular Weight:200.02

Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione

37538-68-4
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$74.00/250mg

39551-54-7
149 suppliers
$45.00/10mg

Yield:39551-54-7 55%

Reaction Conditions:

with phosphorus pentachloride;trichlorophosphate for 6 h;Reflux;

Steps:

2,4-dichloropyrido[3,2-d]pyrimidine (2)
Product 1 (1 g, 6.1 mmol) was placed in suspension in POCl₃(10 mL) after which PCl₅was added (5.1 g, 24.5 mmol, 4.0 eq.). The whole was refluxed for 6 hours and the excess POCl₃was evaporated under reduced pressure. The residue obtained was dissolved in 20 mL dichloromethane and poured onto 30 mL of a water/ice mixture. after 30-minute agitation the aqueous phase was extracted with 3×20 mL dichloromethane. The combined organic phases were dried over anhydrous magnesium sulfate and the solvents evaporated to give the title product 2 (673 mg, 55%) in the form of a yellow solid.

References:

Centre National de la Recherche Scientifique;Universite d'Orleans;Université de Tours;Institute National de la Santé et de la Recherche Médicale (INSERM);CHU Nantes;ROUTIER, Sylvain;BURON, Frédéric;RODRIGUES, Nuno;FOURRIERE-GRANDCLAUDE, Gaëlle;VANDIER, Christophe;CHANTOME, Aurélie;POTIER-CARTEREAU, Marie;GUEGUINOU, Maxime;MARIONNEAU-LAMBOT, Séverine US2021/9581, 2021, A1 Location in patent:Paragraph 0215; 0216

FullText

37538-68-4
63 suppliers
$74.00/250mg

39551-54-7
149 suppliers
$45.00/10mg

References

1462-86-8 Synthesis