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ChemicalBook CAS DataBase List 2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID

2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID synthesis

6synthesis methods
-

Yield:189283-54-3 89%

Reaction Conditions:

Stage #1: [2,6-difluoro-4-(methoxymethoxy)phenyl]trimethylsilanewith sec.-butyllithium in tetrahydrofuran;cyclohexane at -75; for 2 h;
Stage #2: carbon dioxide in tetrahydrofuran;cyclohexane;
Stage #3: with hydrogenchloride pH=1;

References:

Marzi, Elena;Gorecka, Joanna;Schlosser, Manfred [Synthesis,2004,# 10,p. 1609 - 1618]

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