ChemicalBook CAS DataBase List 2,4-Difluorobenzaldehyde

2,4-Difluorobenzaldehyde synthesis

8synthesis methods

Product Name:2,4-Difluorobenzaldehyde
CAS Number:1550-35-2
Molecular formula:C7H4F2O
Molecular Weight:142.1

56456-47-4 Synthesis

56456-47-4
194 suppliers
$5.00/1g

1550-35-2
365 suppliers
$6.00/5g

Yield:1550-35-2 89%

Reaction Conditions:

with 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;copper diacetate in water;acetonitrile at 20; for 6 h;Green chemistry;

Steps:

General procedure: A mixture of alcohol (5.0 mmol), Cu(OAc)₂ (9.1 mg, 0.05 mmol), and TEMPO (7.8 mg, 0.05 mmol) in CH₃CN/H₂O (5/10 mL) was stirred at room temperature for specified time. After completion of the reaction (monitored by TLC, eluents: petroleum ether/ethyl acetate = 4/1), dichloromethane (10 mL) was added to the resulting mixture. The dichloromethane phase was separated, and the aqueous phase was further extracted with dichloromethane (10 mL × 2). The combined organic layers were dried over anhydrous sodium sulfate and concentrated to give a residue, which was purified by column chromatography (eluents: petroleum ether/ethyl acetate = 10/1) to provide the desired product.

References:

Jiang, Jian-An;Du, Jia-Lei;Wang, Zhan-Guo;Zhang, Zhong-Nan;Xu, Xi;Zheng, Gan-Lin;Ji, Ya-Fei [Tetrahedron Letters,2014,vol. 55,# 10,p. 1677 - 1681] Location in patent:supporting information

FullText

201230-82-2 Synthesis