ChemicalBook CAS DataBase List 2,4-Dihydroxy-5-isopropylbenzaldehyde

2,4-Dihydroxy-5-isopropylbenzaldehyde synthesis

5synthesis methods

Product Name:2,4-Dihydroxy-5-isopropylbenzaldehyde
CAS Number:958888-27-2
Molecular formula:C10H12O3
Molecular Weight:180.2

23504-03-2 Synthesis

23504-03-2
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958888-27-2
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Yield:958888-27-2 73.2%

Reaction Conditions:

with trichlorophosphate in N,N-dimethyl-formamide at -5 - 50; for 2.5 h;

Steps:

39.a

a) -5 under,Phosphorus oxychloride (155 mL, 1.64 mol)Was added dropwise to 350 mL of dry DMF,After stirring for 0.5 hour,A solution of 4-isopropylresorcinol (100 g, 0.65 mol)In 200 mL of dry DMF.The reaction mixture was stirred at room temperature for 1 hour,Followed by reaction at 50 ° C for 1 hour,After cooling, slowly pour 315 gSodium hydroxide in 2 L of water.After the mixture was reacted at 70 ° C for 15 minutes,After cooling to room temperature, concentrated hydrochloric acid was acidified to pH = 2-3,Ethyl acetate extraction.The organic phase was washed with saturated brine,Dried over anhydrous sodium sulfate, evaporated to dryness,Silica gel column to obtain a white solid 4E 86.65 g,The yield was 73.2%.

References:

CN103724269,2016,B Location in patent:Paragraph 0610; 0611; 0613; 0614; 0615; 0616

89-84-9 Synthesis