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ChemicalBook CAS DataBase List 2,4-dimethyl-6-hydroxybenzonitrile

2,4-dimethyl-6-hydroxybenzonitrile synthesis

4synthesis methods
55305-43-6 Synthesis
N-Cyano-N-phenyl-p-toluenesulfonaMide

55305-43-6
65 suppliers
$23.00/100mg

108-68-9 Synthesis
3,5-Dimethylphenol

108-68-9
330 suppliers
$9.00/5g

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Yield:56396-59-9 88%

Reaction Conditions:

Stage #1: N-cyano-N-phenyl-p-toluenesulfonamide;3,5-Dimethylphenolwith aluminum (III) chloride;boron trifluoride diethyl etherate in acetonitrile at 80; for 24 h;
Stage #2: with sodium hydroxide in water at 20; for 5 h;Reflux;Solvent;Time;

References:

Zhang, Wu;Li, Tao;Wang, Qingli;Zhao, Wanxiang [Advanced Synthesis and Catalysis,2019,vol. 361,# 21,p. 4914 - 4918] Location in patent:supporting information