2,4-dimethyl-7,8-dihydroquinolin-5(6H)-one synthesis
2synthesis methods
- Product Name:2,4-dimethyl-7,8-dihydroquinolin-5(6H)-one
- CAS Number:34192-19-3
- Molecular formula:C11H13NO
- Molecular Weight:175.23
Yield:-
Steps:
5.a 2,4-Dimethyl-5-[3-(4-diphenylmethylpiperazine-1-yl)-2-hydroxypropoxy]quinoline
(a) With 5.0 g of acetylacetone was mixed 2.8 g of 3-amino-2-cyclohexenone, and the liquid was then heated with stirring at 70° C. for 1 hour. The heating was further continued at a temperature of 160° to 170° C. for 9 hours. Excess acetylacetone and water were distilled off under reduced pressure, and the residue was then purified through a silica gel column chromatograph by the use of an effluent of chloroform:methanol=50:1, thereby obtaining 1.85 g of 2,4-dimethyl-5,6,7,8-tetrahydro-5-oxoquinoline. m.p.: 54°-57° C.
References:
US5112817,1992,A
