2-(4-FLUORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE synthesis
- Product Name:2-(4-FLUORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE
- CAS Number:76606-39-8
- Molecular formula:C10H10FN3
- Molecular Weight:191.2
Yield: 75%
Reaction Conditions:
with hydrogenchloride in water for 0.416667 h;Heating;
Steps:
General procedure for the synthesis of 1-aryl-3-methyl-5-aminopyrazoles (3a-e).
General procedure: To a solution of the corresponding arylhydrazine (1a-e) (10 mmol) in concentrated hydrochloric acid (5 mL), 820 mg of 3-aminocrotonitrile (2) (10 mmol) was added with magnetic stirring. The mixture was left to react for 10 minutes and then more HCl was added (5 mL) while heating for 15 additional minutes. After completion of the reaction, a yellow solution was obtained which was then cooled by addition of crushed ice and neutralized with concentrated ammonium hydroxide. Finally, the formed precipitate corresponding to aminopyrazoles 3a-e, was vacuum filtered and washed with cold water.
References:
Becerra-Rivas, Christian;Cuervo-Prado, Paola;Orozco-Lopez, Fabian [Synthetic Communications,2019,vol. 49,# 3,p. 367 - 376] Location in patent:supporting information
1118-61-2
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76606-39-8
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5417-82-3
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76606-39-8
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2469-99-0
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76606-39-8
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$45.00/25mg