ChemicalBook CAS DataBase List 2-(4-fluorophenyl)-2-phenyl-acetonitrile

2-(4-fluorophenyl)-2-phenyl-acetonitrile synthesis

8synthesis methods

Product Name:2-(4-fluorophenyl)-2-phenyl-acetonitrile
CAS Number:719-82-4
Molecular formula:C14H10FN
Molecular Weight:211.23

Benzeneacetonitrile, 4-fluoro-α-hydroxy-

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2-(4-fluorophenyl)-2-phenyl-acetonitrile

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Yield:-

Reaction Conditions:

with sulfuric acid in benzene;

Steps:

R.1.1 2-(p-Fluorophenyl)-2-phenylacetonitrile

REFERENCE EXAMPLE 1-1 2-(p-Fluorophenyl)-2-phenylacetonitrile A solution of p-fluoromandelonitrile (45 g) in benzene (90 g) was added portionwiste to sulfuric acid (85 ml) with constant stirring at 5°-10° C. After completion of portionwise addition, the mixture was further stirred for 30 minutes. The reaction mixture was then diluted with water (500 ml) and extracted with ethyl acetate (300 ml*2). The extract was washed with water, dried over anhydrous sodium sulfate and concentrated to provide a colorless oil (59.5 g). Using the corresponding mandelonitrile derivative and chlorobenzene, the following compounds 1-2 and 1-3 were respectively synthesised in otherwise the same manner as Reference Example 1-1. Compound 1-2

References:

US5607939,1997,A