2-(4-fluorophenyl)-4H-chromen-4-one synthesis

13synthesis methods

Product Name:2-(4-fluorophenyl)-4H-chromen-4-one
CAS Number:1645-21-2
Molecular formula:C15H9FO2
Molecular Weight:240.23

459-57-4 Synthesis

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582-24-1 Synthesis

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1645-21-2
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Yield:1645-21-2 93%

Reaction Conditions:

with 1-butyl-3-methylimidazolium chromate in butan-1-ol at 60; for 2 h;

Steps:

5 Example 5: synthesis of 4'-fluoroflavone

In 10 ml in the reaction kettle, successively added 0.2482g (2mmol) 4-fluoro benzaldehyde, 0.2723g (2mmol) 2-hydroxy acetophenone and 0.2367g (0.6mmol) of the ionic liquid catalyst [Bmim]₂[CrO₄], and 0.4447g (6mmol) butanol solvent, stirring after mixing, heating to reaction temperature 60 °C, stirring reaction in the open environment 2h, cooled to the room temperature after the reaction, water extraction, static split-phase, through the corresponding solvent is removed by reduced pressure distillation after the n-butyl alcohol, and recrystallization to column chromatography separation to obtain the target product 4'-fluoro flavone, the yield is 93%, the nuclear magnetic resonance hydrogen spectrum, carbon spectrum and high-resolution mass spectrometry to determine its structural formula is:

References:

CN105294627,2016,A Location in patent:Paragraph 0044; 0045; 0046; 0047; 0048

135276-47-0 Synthesis