![](/CAS/GIF/1645-21-2.gif)
2-(4-fluorophenyl)-4H-chromen-4-one synthesis
- Product Name:2-(4-fluorophenyl)-4H-chromen-4-one
- CAS Number:1645-21-2
- Molecular formula:C15H9FO2
- Molecular Weight:240.23
Yield:1645-21-2 93%
Reaction Conditions:
with 1-butyl-3-methylimidazolium chromate in butan-1-ol at 60; for 2 h;
Steps:
5 Example 5: synthesis of 4'-fluoroflavone
In 10 ml in the reaction kettle, successively added 0.2482g (2mmol) 4-fluoro benzaldehyde, 0.2723g (2mmol) 2-hydroxy acetophenone and 0.2367g (0.6mmol) of the ionic liquid catalyst [Bmim]2[CrO4], and 0.4447g (6mmol) butanol solvent, stirring after mixing, heating to reaction temperature 60 °C, stirring reaction in the open environment 2h, cooled to the room temperature after the reaction, water extraction, static split-phase, through the corresponding solvent is removed by reduced pressure distillation after the n-butyl alcohol, and recrystallization to column chromatography separation to obtain the target product 4'-fluoro flavone, the yield is 93%, the nuclear magnetic resonance hydrogen spectrum, carbon spectrum and high-resolution mass spectrometry to determine its structural formula is:
References:
CN105294627,2016,A Location in patent:Paragraph 0044; 0045; 0046; 0047; 0048
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