![](/CAS/GIF/69489-37-8.gif)
2,4-Imidazolidinedione, 5-(4-methylphenyl)- synthesis
- Product Name:2,4-Imidazolidinedione, 5-(4-methylphenyl)-
- CAS Number:69489-37-8
- Molecular formula:C10H10N2O2
- Molecular Weight:190.2
Yield:-
Reaction Conditions:
in aq. phosphate buffer;dimethyl sulfoxide at 50;Kinetics;
Steps:
1.1.2; 2.2.1
PGAH (1a) and two PGAH derivatives (1b and 1c) (0.3 mmol, 1.0 eq.) were dissolved in 1 :1 v/v mixture of PBS:dimethylsulfoxide (DMSO) (10 mL). Urea (901 mg, 15 mmol, 50 eq.) was dissolved in the PGAH solution which was subsequently magnetically stirred at 50 °C. Samples (50 pL) from the reaction mixture were taken at different time points, diluted 10 (1a) or 15 (1b and 1c) times with 1 :1 v/v DMSO:PBS (500 or 700 pl_) and subsequently diluted another 10x using the same solvent mixture (thus resulting in a final 100 or 150 times dilution, respectively). The concentrations of the PGAH (derivatives) 1a-c in the 100 or 150 times diluted samples were determined by UV spectroscopy (260, 263 and 270 nm, for 1a, 1b and 1c, respectively). A calibration curve was prepared using a dilution series in 1 :1 v/v mixture of PBS:DMSO (final concentrations varied from 0.030-0.360 mM) from a stock solution of the PGAH (derivatives) (30 mM) in 1 :1 (v/v) DMSO:PBS. The /(PFo-values for the PGAH analogues were determined from the slopes of the plots of log [PGAH] versus time.
References:
STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN;UNIVERSITEIT UTRECHT HOLDING B.V.;UMC UTRECHT HOLDING B.V. WO2021/99577, 2021, A1 Location in patent:Page/Page column 7; 30-31; 34-35
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