2-(4-Iodo-phenoxy)-ethylaMine synthesis

5synthesis methods

Product Name:2-(4-Iodo-phenoxy)-ethylaMine
CAS Number:151978-97-1
Molecular formula:C8H10INO
Molecular Weight:263.08

151978-98-2
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151978-97-1
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Yield: 88%

Reaction Conditions:

with hydrogenchloride in diethyl ether;ethanol at 0 - 20; for 12 h;Concentration;Solvent;

Steps:

14.3.1 Step-3.i: Synthesis of2-(4-iodophenoxy)ethan- i-amine
10364] To a stirred solution of tert-butyl (2-(4-iodophe- noxy)ethyl)carbamate (25 g, 68.6 mmol, Example 3, Step-2) in ethanol (50 mE) was added at 0° C., 2M HC1 in ether (250 mE). The reaction mixture was stirred for 12 h at room temperature. After completion of reaction, reaction mixture was basified with saturated NaHCO3, extracted with 10% MeOR in DCM. Organic layer was concentrated under reduced pressure and the crude material was used in next step without further purification (16 g, 88%).

References:

Eisai R&D Management Co., Ltd.;BOCK, Mark;HAO, Ming-Hong;KORPAL, Manav;NYAVANANDI, Vijay Kumar;PUYANG, Xiaoling;SAMAJDAR, Susanta;SMITH, Peter Gerard;WANG, John;ZHENG, Guo Zhu;ZHU, Ping US2016/347717, 2016, A1 Location in patent:Paragraph 0363; 0364