2-(4-METHOXY-PHENYL)-1-METHYL-PYRROLIDINE synthesis

4synthesis methods

Product Name:2-(4-METHOXY-PHENYL)-1-METHYL-PYRROLIDINE
CAS Number:104936-83-6
Molecular formula:C12H17NO
Molecular Weight:191.27

17061-63-1
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2-(4-METHOXY-PHENYL)-1-METHYL-PYRROLIDINE

104936-83-6
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: KH / tetrahydrofuran / 0 - 25 °C
2: 1.) Et₃OBF₄ / 1.) 1,2-dichloroethane, reflux, 8 h, 2.) room temp
3: 1.) t-BuLi / 1.) THF -78 deg C, 1.5 h, 2.) -78 deg C-room temp.
4: hydrazine hydrate / ethanol; acetic acid / 25 °C

References:

Meyers;Marra [Tetrahedron Letters,1985,vol. 26,# 48,p. 5863 - 5866]