2-(4-METHOXY-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE synthesis

12synthesis methods

Product Name:2-(4-METHOXY-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE
CAS Number:139962-68-8
Molecular formula:C14H12N2O
Molecular Weight:224.26

13534-99-1 Synthesis

13534-99-1
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$4.00/1g

100-06-1 Synthesis

100-06-1
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$18.19/25g

2-(4-METHOXY-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE

139962-68-8
17 suppliers
$65.00/500mg

Yield:139962-68-8 87%

Reaction Conditions:

Stage #1: 1-(4-methoxyphenyl)ethanonewith allyl(1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene)palladium(IV) chloride;sodium hexamethyldisilazane in tetrahydrofuran at 20; for 0.0833333 h;Inert atmosphere;
Stage #2: 2-Amino-3-bromopyridine in tetrahydrofuran at 20 - 105; for 4 h;Inert atmosphere;regioselective reaction;

References:

Spergel, Steven H.;Okoro, Danielle R.;Pitts, William [Journal of Organic Chemistry,2010,vol. 75,# 15,p. 5316 - 5319] Location in patent:supporting information; experimental part