ChemicalBook CAS DataBase List 2-(4-(methoxycarbonyl)phenyl)acetic acid

2-(4-(methoxycarbonyl)phenyl)acetic acid synthesis

12synthesis methods

Product Name:2-(4-(methoxycarbonyl)phenyl)acetic acid
CAS Number:22744-12-3
Molecular formula:C10H10O4
Molecular Weight:194.18

4-METHOXYCARBONYLMETHYL-BENZOIC ACID METHYL ESTER

52787-14-1
142 suppliers
$12.00/1g

2-(4-(methoxycarbonyl)phenyl)acetic acid

22744-12-3
76 suppliers
$18.00/100mg

Yield: 94.4%

Reaction Conditions:

with lithium hydroxide monohydrate;water in tetrahydrofuran;ethanol at 25; for 10 h;

Steps:

5 Example 5; preparation of 2- (4- (methoxycarbonyl) phenyl)acetic acid (5)
2- (4- (methoxycarbonyl) phenyl) acetic acid (58,24.04 dirty 1) to the reaction flask, 31111 water, 31111 5ml tetrahydrofuran and a mixed solvent of ethanol raw materials were dissolved. Was then added Η0Η-Η20 (1.068,25.24ππο1) α25 ° C was stirred for 10 hours the reaction is substantially complete. The solution was spin-off in tetrahydrofuran and ethanol, followed by addition of 26ml of dilute hydrochloric acid (lmmol / L), and a white precipitate formed, suction, infrared drying to give a white solid 4.4g, 94.4% yield

References:

China Pharmaceutical University;Xiang, Hua;Xu, Pei;Wang, Wenbin;Qian, Zhouyang;Chen, Mingqi;You, Qidong CN105541777, 2016, A Location in patent:Paragraph 0015; 0062; 0063; 0064

67-56-1 Synthesis