2-(4-Methoxyphenyl)-2-Methylpropan-1-aMine synthesis
- Product Name:2-(4-Methoxyphenyl)-2-Methylpropan-1-aMine
- CAS Number:51558-25-9
- Molecular formula:C11H17NO
- Molecular Weight:179.26
5351-07-5
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51558-25-9
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Yield:51558-25-9 86%
Reaction Conditions:
with lithium aluminium tetrahydride in diethyl ether at 0 - 20; for 4 h;
Steps:
13.2 Step 2: Preparation of2-(4-methoxyphenyl)-2-methylpropane-1 -amine
2-(4-methoxyphenyl)-2-methylpropanenitrile(2.00 g, 11.41 mmol) prepared in step 1 was dissolved indiethylether (100 mE), and the temperature was lowered to0° C. Lithium aluminum hydride (0.52 g, 13.70 mmol) wasadded thereto, followed by stirring at room temperature for 4 hours. Upon completion of the reaction, a new spot was formed under the starting material, which was confirmed by TEC. The reaction mixture was cooled in an ice bath. 2 N sodium hydroxide was added to terminate the reaction, followed by separating the diethylether layet The water layer was extracted twice with ethylacetate, followed by washing with water and brine. The organic layer was dried over sodium sulfate and concentrated under reduced pressure. Then, purification was performed by MPLC to give the target compound 2-(4-methoxyphenyl)-2-methylpropane-1 - amine (1.75 g, 9.76 mmol, yield: 86%).10308] ‘H-NMR (300 MHz, CDC13) ? 7.27 (d, J=6.0 Hz,2H), 6.89 (d, J=6.0 Hz, 2H), 3.80 (s, 3H), 2.76 (s, 2H), 1.28(s, 6H); El/MS 179 [M]
References:
US2018/111905,2018,A1 Location in patent:Paragraph 0302; 0307; 0308
55770-61-1
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51558-25-9
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