ChemicalBook CAS DataBase List 2-(4-METHYLPHENYL)ETHANETHIOAMIDE

2-(4-METHYLPHENYL)ETHANETHIOAMIDE synthesis

6synthesis methods

Product Name:2-(4-METHYLPHENYL)ETHANETHIOAMIDE
CAS Number:97426-53-4
Molecular formula:C9H11NS
Molecular Weight:165.26

622-97-9 Synthesis

622-97-9
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$10.00/5mL

97426-53-4
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$59.10/250mg

Yield:97426-53-4 45%

Reaction Conditions:

with potassium phosphate;ammonium bicarbonate;sulfur in dimethyl sulfoxide at 100; for 24 h;Schlenk technique;Inert atmosphere;

Steps:

31

In a dry 25 mL Schlenk reaction tube, 23.7 mg of ammonium bicarbonate was added.71 mg of 4-methylstyrene, 38.4 mg of sulfur, 127 mg of tripotassium phosphate and 1.5 mL of dimethyl sulfoxide.Stir at 100 ° C for 24 hours under nitrogen.After completion of the reaction, the mixture was cooled to room temperature, and the insoluble material was removed by filtration, washed with water and ethyl acetate.Directly through the silica gel column (the ratio of ethyl acetate to petroleum ether is 1:50-1:3),The product was obtained in 22.3 mg, the yield was 45%.

References:

CN108689895,2018,A Location in patent:Paragraph 0190-0192