2-(4-Methylphenyl)-quinazolin-4(3H)-one synthesis
- Product Name:2-(4-Methylphenyl)-quinazolin-4(3H)-one
- CAS Number:18818-41-2
- Molecular formula:C15H12N2O
- Molecular Weight:236.27
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Yield:18818-41-2 96%
Reaction Conditions:
with ammonium hydroxide;oxygen;copper(I) bromide in 1-methyl-pyrrolidin-2-one at 60; for 30 h;
Steps:
19 preparation of 2-(4-tolyl)quinazolin-4(3H)-one
A solution of 2- (4-tolyl) -1H-indole in 0.25 mmol,Ammonia water 0.10g,0.0125 mmol of cuprous bromide,N-methylpyrrolidone 2.0 mL was added to 10 mL of the reaction tube,Placed in an oil bath at 60 ° C,Oxygen under the protection of 30h reaction.Stop the reaction,Cool to room temperature.The reaction solution was diluted with methylene chloride,Extracted three times with water,The organic phase was dried over anhydrous Na2SO4,filter,And 56.6 mg of the target product was isolated by column chromatography.The yield was 96%.
References:
CN104496915,2017,B Location in patent:Paragraph 0074; 0075; 0076
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