2,4-Pyrrolidinedione, 3-acetyl-5-(2-methylpropyl)- synthesis

Yield:-

Steps:

Multi-step reaction with 5 steps
1: magnesium sulfate / dichloromethane / 16 h / 0 - 20 °C
2: N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide / tetrahydrofuran / 0.5 h / 0 °C
3: phenyl isocyanate; triethylamine / toluene / 24 h / 0 - 20 °C / Inert atmosphere
4: 5%-palladium/activated carbon; hydrogen / ethanol / 0.5 h
5: sodium hydroxide / tetrahydrofuran; water / 0.01 h / Microwave irradiation

References:

Katsuta, Ryo;Ichijo, Hiroki;Oouchi, Ginka;Yajima, Arata;Ishigami, Ken;Nukada, Tomoo [Tetrahedron Letters,2018,vol. 59,# 24,p. 2352 - 2355]