2-(5-Acetylthiophen-2-yl)-isonicotinic acid synthesis
- Product Name:2-(5-Acetylthiophen-2-yl)-isonicotinic acid
- CAS Number:893723-57-4
- Molecular formula:C10H7NO2S
- Molecular Weight:205.23
66572-56-3
345 suppliers
$7.00/5g
5713-61-1
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$238.00/50mL
893723-57-4
15 suppliers
$157.00/250mg
Yield:893723-57-4 81%
Reaction Conditions:
Stage #1: thiophen-2-yl magnesium bromidewith titanium(IV) tetraethanolate in tetrahydrofuran at 20; for 0.5 h;Inert atmosphere;
Stage #2: 2-bromoisonicotinic acidwith tributylphosphine;cobalt(II) chloride in tetrahydrofuran at 20;Inert atmosphere;chemoselective reaction;
References:
Zeng, Jing;Liu, Kun Ming;Duan, Xin Fang [Organic Letters,2013,vol. 15,# 20,p. 5342 - 5345] Location in patent:supporting information