2-(5-AMINO-3-PHENYL-1H-PYRAZOL-1-YL)ETHANOL synthesis

Yield:14085-42-8 79%

Reaction Conditions:

with acetic acid in ethanol; for 4 h;Heating / reflux;

Steps:

6 2-(5-Amino-3-phenyl-pyrazol-1-yl)-ethanol

2-(5-Amino-3-phenyl-pyrazol-1-yl)-ethanol Benzoylacetonitrile (25 g, 0.17 mol) was suspended in a mixture of 125 mL reagent grade anhydrous alcohol and 20 mL glacial acetic acid. 2-Hydroxyethylhydrazine (14.4 g, 1.1 equiv) dissolved in 35 mL alcohol was added all at once. The mixture was heated at reflux for 4 h, cooled, water was added to make 500 mL total volume and the solution was chilled in a refrigerator overnight. Crystals were filtered cold on a Buchner funnel, washed with cold water and dried on high vacuum to give the desired product (27.2 g, 79%).

References:

US2007/232603,2007,A1 Location in patent:Page/Page column 26