![](/CAS/GIF/67127-91-7.gif)
2,5-BIS-BENZYLOXY-BENZOIC ACID synthesis
- Product Name:2,5-BIS-BENZYLOXY-BENZOIC ACID
- CAS Number:67127-91-7
- Molecular formula:C21H18O4
- Molecular Weight:334.37
![Benzoic acid, 2,5-bis(phenylmethoxy)-, phenylmethyl ester](/CAS/20210305/GIF/78283-37-1.gif)
78283-37-1
0 suppliers
inquiry
![2,5-BIS-BENZYLOXY-BENZOIC ACID](/CAS/GIF/67127-91-7.gif)
67127-91-7
51 suppliers
$120.00/1g
Yield:67127-91-7 91%
Reaction Conditions:
with sodium hydroxide in 1,4-dioxane;methanol;water; for 14 h;Reflux;
Steps:
2,5-Dibenzyloxybenzoic acid (13)
A solution of 1.0 g (2.4 mmol) of ester 25 and 0.19 g (4.7 mmol) of sodium hydroxide in 15 mL of methanol, dioxane, and water (1:1:1) was stirred under reflux for 14 h, cooled to 25oC, and most of the organic solvents were removed from a rotary evaporator. The residue was diluted with water, acidified with 1 N HCl, extracted twice with ethyl acetate (50 mL), and the ethyl acetate layers were combined, washed with water and brine, dried (MgSO4), concentrated, and column chromatographed using a mixture of hexane and ethyl acetate (1:1) as eluent to give 0.72 g (91% yield) of compound 13.15 1H NMR δ 11.06 (s, 1 H), 7.81 (d, J = 3.1 Hz, 1 H), 7.43 - 7.32 (m, 10 H), 7.17 (dd, J = 9.0, 3.1 Hz, 1 H), 7.07 (d, J = 9.0 Hz, 1 H), 5.26 (s, 2 H), 5.08 (s, 2 H); 13C NMR δ 165.3, 153.9, 151.9, 136.6, 134.6, 129.4, 129.4, 128.8, 128.4, 128.2, 127.8, 123.0, 119.0, 117.8, 115.1, 73.2, 70.9.
References:
Thapa, Mahendra;Kim, Yunjeong;Desper, John;Chang, Kyeong-Ok;Hua, Duy H. [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 1,p. 353 - 356] Location in patent:supporting information; experimental part
![methyl 2,5-bis(benzyloxy)benzoate](/CAS/20180703/GIF/106296-25-7.gif)
106296-25-7
4 suppliers
inquiry
![2,5-BIS-BENZYLOXY-BENZOIC ACID](/CAS/GIF/67127-91-7.gif)
67127-91-7
51 suppliers
$120.00/1g
![2,5-Dihydroxybenzoic acid](/CAS/GIF/490-79-9.gif)
490-79-9
490 suppliers
$5.00/100mg
![2,5-BIS-BENZYLOXY-BENZOIC ACID](/CAS/GIF/67127-91-7.gif)
67127-91-7
51 suppliers
$120.00/1g
![Methyl 2,5-dihydroxybenzoate](/CAS/GIF/2150-46-1.gif)
2150-46-1
226 suppliers
$6.00/1g
![2,5-BIS-BENZYLOXY-BENZOIC ACID](/CAS/GIF/67127-91-7.gif)
67127-91-7
51 suppliers
$120.00/1g
![Benzyl bromide](/CAS/GIF/100-39-0.gif)
100-39-0
423 suppliers
$10.00/10g
![2,5-BIS-BENZYLOXY-BENZOIC ACID](/CAS/GIF/67127-91-7.gif)
67127-91-7
51 suppliers
$120.00/1g