2,5-DIFLUOROBENZYLMAGNESIUM BROMIDE synthesis

Yield:-

Reaction Conditions:

with iodine;magnesium in diethyl ether; for 1.66667 h;Heating / reflux;

Steps:

To a suspension of magnesium strip (763 mg) in diethyl ether (7 mL) was added iodine (one crystal) followed by 0.4 mL of 2- (bromomethyl)-1, 4-difluorobenzene under nitrogen. The reaction was initiated with a heat gun and 2-(bromomethyl)-1, 4-difluorobenzene (5.0 g, 24.25 mmol) in diethyl ether (7 mL) was added slowly. After addition was completed the reaction mixture was refluxed for 100 minutes, cooled to room temperature.

References:

WO2005/61499,2005,A1 Location in patent:Page/Page column 24