ChemicalBook CAS DataBase List 2,5-DIHYDROXY-1,4-BENZENEDIACETIC ACID

2,5-DIHYDROXY-1,4-BENZENEDIACETIC ACID synthesis

5synthesis methods

Product Name:2,5-DIHYDROXY-1,4-BENZENEDIACETIC ACID
CAS Number:5488-16-4
Molecular formula:C10H10O6
Molecular Weight:226.18

1,4-Benzenediacetic acid, 2,5-bis(acetyloxy)-

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Yield:5488-16-4 78%

Reaction Conditions:

with sulfuric acid in water;

Steps:

The protected diacid (0.09 g, 0.29 mmol) was dissolved in 3 mL 2% sulfuric acid and stirred over the weekend. Extraction was performed 3 times with 15 mL ethyl acetate and 5 mL water. The ethyl acetate layer was collected and the solvent pumped off on the rotary evaporator. Brownish solid residue remained after drying in the fume hood. (0.045 g, 0.23 mmol, 78% yield) TLC (20% methanol/chloroform) Rf=0.190

References:

US2006/223993,2006,A1 Location in patent:Page/Page column 6