![](/CAS/GIF/107099-99-0.gif)
2,5-Dimethoxyphenylboronic acid synthesis
- Product Name:2,5-Dimethoxyphenylboronic acid
- CAS Number:107099-99-0
- Molecular formula:C8H11BO4
- Molecular Weight:181.98
![Trimethyl borate](/CAS/GIF/121-43-7.gif)
121-43-7
345 suppliers
$14.00/25mL
![1-Bromo-2,5-dimethoxybenzene](/CAS/GIF/25245-34-5.gif)
25245-34-5
233 suppliers
$8.00/5g
![2,5-Dimethoxyphenylboronic acid](/CAS/GIF/107099-99-0.gif)
107099-99-0
280 suppliers
$6.00/1g
Yield:107099-99-0 50%
Reaction Conditions:
Stage #1: 1-bromo-2,5-dimethoxybenzenewith n-butyllithium in tetrahydrofuran at -78; for 2 h;
Stage #2: Trimethyl borate in tetrahydrofuran at 20;
Steps:
3.1 Synthesis Example 3. Synthesis of Compound 140. Synthesis Example 3-(1). Synthesis of Intermediate 3-a
In a 1-L round-bottom flask reactor, 2-bromo-1,4-dimethoxybenzene (50 g, 230 mmol) and tetrahydrofuran (400 ml) were dissolved. After the mixture was cooled to -78° C., it was added with drops of N-butyl lithium (167 ml, 280 mmol). At the same temperature, the mixture was stirred for 2 hrs before the addition of trimethyl borate (36 ml, 320 mmol). Stirring was conducted overnight at room temperature. After completion of the reaction, 2 N HCl was dropwise added for acidification. Extraction with water and ethyl acetate gave an organic layer which was then dried over magnesium sulfate and concentrated in a vacuum. Recrystallization in heptane and toluene afforded
References:
US2017/18723,2017,A1 Location in patent:Paragraph 0157-0158
![Trimethyl borate](/CAS/GIF/121-43-7.gif)
121-43-7
345 suppliers
$14.00/25mL
![1-Bromo-2,5-dimethoxybenzene](/CAS/GIF/25245-34-5.gif)
25245-34-5
233 suppliers
$8.00/5g
![Water](/CAS/GIF/7732-18-5.gif)
7732-18-5
462 suppliers
$13.50/100ML
![2,5-Dimethoxyphenylboronic acid](/CAS/GIF/107099-99-0.gif)
107099-99-0
280 suppliers
$6.00/1g
![1-Bromo-2,5-dimethoxybenzene](/CAS/GIF/25245-34-5.gif)
25245-34-5
233 suppliers
$8.00/5g
![2,5-Dimethoxyphenylboronic acid](/CAS/GIF/107099-99-0.gif)
107099-99-0
280 suppliers
$6.00/1g
![Trimethyl borate](/CAS/GIF/121-43-7.gif)
121-43-7
345 suppliers
$14.00/25mL
![1,4-Dimethoxybenzene](/CAS/GIF/150-78-7.gif)
150-78-7
512 suppliers
$5.00/25g
![2,5-Dimethoxyphenylboronic acid](/CAS/GIF/107099-99-0.gif)
107099-99-0
280 suppliers
$6.00/1g
![1,4-Dimethoxybenzene](/CAS/GIF/150-78-7.gif)
150-78-7
512 suppliers
$5.00/25g
![2,5-Dimethoxyphenylboronic acid](/CAS/GIF/107099-99-0.gif)
107099-99-0
280 suppliers
$6.00/1g