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2,5-Dimethyl-4-phenylthiazole, 97% synthesis

10synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: KHCO3 / 1,2-dimethoxy-ethane / 4.5 h
1.2: 44 percent / pyridine; trifluoroacetic anhydride / 1,2-dimethoxy-ethane / 0 - 20 °C
2.1: LiNEt2 / tetrahydrofuran; hexane / 0.5 h / -78 - -50 °C
2.2: tetrahydrofuran; hexane / -78 °C

References:

Evans, David A.;Cee, Victor J.;Smith, Thomas E.;Santiago, Keith J. [Organic Letters,1999,vol. 1,# 1,p. 87 - 90]