2,5-DIMETHYLQUINAZOLIN-4-OL synthesis

Yield:147006-56-2 90.5%

Reaction Conditions:

with ammonium hydroxideReflux;

Steps:

2 Step 2: synthesis of 2,5-dimethylquinazolin-4(3H)-one 40-c

A mixture of intermediate 40-b (20.0 g, 114 mmol) and ammonium hydroxide (50 ml)was refluxed overnight. The mixture was cooled to 25°C. The solid was collected byfiltration and washed with water. The filter cake was dried under vacuum at 40°C for 1hour to yield the title intermediate 40-c (20 g, 90.5%).

References:

WO2016/91774,2016,A1 Location in patent:Page/Page column 48