ChemicalBook CAS DataBase List 2,5-Dimethylquinoline

2,5-Dimethylquinoline synthesis

14synthesis methods

Product Name:2,5-Dimethylquinoline
CAS Number:26190-82-9
Molecular formula:C11H11N
Molecular Weight:157.21

64-17-5 Synthesis

64-17-5
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108-44-1 Synthesis

108-44-1
365 suppliers
$9.00/1g

93-37-8 Synthesis

93-37-8
64 suppliers
$295.00/1g

26190-82-9
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Yield:93-37-8 51% ，26190-82-9 45%

Reaction Conditions:

Stage #1: ethanolwith iron chromite;dihydrogen peroxide in water at 20; for 2 h;UV-irradiation;
Stage #2: 1-amino-3-methylbenzene in water; for 0.0833333 h;

Steps:

Photoactivated tandem synthesis of substitutedquinolines.

General procedure: Synthesis with the use of photoactivation was carried out in a photocatalytic installation Photo Catalytic Reactor Lelesil Innovative Systems with a quartz reactor of 500 mL capacity (Strohmeier type photoreactor with a magnetic stirrer). The reactor was charged with 4.8 mmol of catalyst Fe(CrO₂)₂ and 120 mmol of an appropriate alcohol, the reactor was shaken and left standing for 24 h to reach an equilibrium. Just before the reaction the dispersion of catalyst in the alcohol was subjected to microwave irradiation for 10 min(Ultrasound bath “Sapfir”, power 55 W). 102 mL of 5% aqueous solution of H₂O₂ (150 mmol of hydrogen peroxide) was added to the treated dispersion. The reactor was attached to the installation in keeping with the instructions of the producer. Light source was a Hg-lamp of moderate pressure of the power 250 W. Spectral composition of radiation by energy was as follows: 48% UV range, 43% visible range, and 9% IR range. Spectral range 222-1368 nm. The light beam went to the system through a temperature-controlled water layer (20°C). Photoactivation time 120 min. Then to the reaction mixture 50 mmol of arylamine was added, the mixture was stirred for 5 min and worked up as in the experiments without photoactivation.

References:

Makhmutov [Russian Journal of Organic Chemistry,2018,vol. 54,# 8,p. 1166 - 1172][Zh. Org. Khim.,2018,vol. 54,# 8,p. 1156 - 1161,6]

108-44-1 Synthesis

108-44-1
365 suppliers
$9.00/1g