(2,5-dimethylthiophen-3-yl)methanol synthesis

6synthesis methods

Product Name:(2,5-dimethylthiophen-3-yl)methanol
CAS Number:875238-39-4
Molecular formula:C7H10OS
Molecular Weight:142.22

26421-44-3 Synthesis

26421-44-3
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875238-39-4
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Yield:875238-39-4 800 mg

Reaction Conditions:

with methanol;sodium tetrahydroborate at 18 - 25; for 1 h;

Steps:

18.3 18.3 Preparation of(2,5-dimethylthiophen-3-yl)methanol

To a stirred solution of 2,5-dimethylthiophene-3-carbaldehyde (1 g, 7.14 mmol) in MeOH (5 mL) at RT wasadded NaBH4 (542 mg, 14.28 mmol) in portions. After 1 h,a saturated ammonium chloride solution (1 0 mL) was addedto quench the reaction and extracted with EtOAc (20 mLx3).The combined organic phase was dried over Na2S04 andconcentrated. The residue was purified by silica-gel columnchromatography (Et0Ac/hexane=1:6) to give 800 mg of(2,5-dimethylthiophen-3-yl)methanol as a colorless oil. GCMS:142 (M+).

References:

US2018/258065,2018,A1 Location in patent:Paragraph 0129; 0227