2,5-PyriMidinediaMine, N2-3-pyridinyl- synthesis
- Product Name:2,5-PyriMidinediaMine, N2-3-pyridinyl-
- CAS Number:910904-48-2
- Molecular formula:C9H9N5
- Molecular Weight:187.2
910904-44-8
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Yield:910904-48-2 90%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol; for 2.5 h;
Steps:
29
Example 29. 7V-Pyridin-3-vI-pyriinidine-2,5-diamine (19); [0163] Compound 18 described in Example 28 (0.36 g, 0.476 mmol, 1 equiv) was combined with 10% palladium on carbon (0.3 g) and flushed with argon. Reactants were then diluted with methanol (15 mL) and reaction atmosphere was evacuated and replaced with hydrogen. Hydrogen balloon was affixed and reaction was allowed to stir for 2.5 hours. Argon was then bubbled through reaction mixture and contents were filtered though a pad of Celite. Solvents were evaporated to provide crude product. Trituration with heptane followed by filtration provided the desired amine as a white solid (0.28 g, w 0 ).
References:
WO2006/101977,2006,A2 Location in patent:Page/Page column 52
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