ChemicalBook CAS DataBase List 2,6-bis((1H-imidazol-1-yl)methyl)pyridine

2,6-bis((1H-imidazol-1-yl)methyl)pyridine synthesis

6synthesis methods

Product Name:2,6-bis((1H-imidazol-1-yl)methyl)pyridine
CAS Number:177428-70-5
Molecular formula:C13H13N5
Molecular Weight:239.28

288-32-4 Synthesis

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7703-74-4 Synthesis

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2,6-bis((1H-imidazol-1-yl)methyl)pyridine

177428-70-5
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Yield:177428-70-5 82%

Reaction Conditions:

with tetrabutylammomium bromide;potassium carbonate in water;toluene at 20; for 8 h;Temperature;Solvent;Reagent/catalyst;

Steps:

1; 3 Example 3:The synthesis method of the water-soluble metal ion fluorescent probe molecule 1 [2,6-bis(1-imidazolyl)methylpyridine] of the invention is as follows:

Synthesis of 2,6-bis(1-imidazolyl)methylpyridine: Imidazole (255.7 mg, 3.76 mmol) was weighed into a 25 mL flask, and 10 mL of toluene was added.Potassium carbonate (1.56 g, 11.28 mmol) and tetrabutylammonium bromide (41.7 mg, 0.13 mmol) were weighed into a 10 mL flask, and 5 mL of water was added.The aqueous solution was added to the toluene solution, and 2,6-dibromomethylpyridine (500 mg, 1.88 mmol) was added with stirring.Then stir at room temperature for 8 hours.A solid precipitated and the solid was filtered and dried to give compound 1 (368.2mg, 82%).

References:

CN109535129,2019,A Location in patent:Paragraph 0037-0041; 0046-0049

7703-74-4 Synthesis

7703-74-4
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$52.00/1g