ChemicalBook CAS DataBase List 2,6-di-tert-butyl-4-hydroxyphenyl acetate

2,6-di-tert-butyl-4-hydroxyphenyl acetate synthesis

3synthesis methods

Product Name:2,6-di-tert-butyl-4-hydroxyphenyl acetate
CAS Number:32102-41-3
Molecular formula:C16H24O3
Molecular Weight:264.36

2,6-di-tert-butyl-4-methoxyphenyl acetate(WXG03403)

75169-17-4
1 suppliers
inquiry

2,6-di-tert-butyl-4-hydroxyphenyl acetate

32102-41-3
11 suppliers
inquiry

Yield:32102-41-3 92.4%

Reaction Conditions:

with chloro-trimethyl-silane;sodium iodide in acetonitrile; for 8 h;Heating / reflux;

Steps:

14

Example 14 Synthesis of 4-acetoxy-3,5-di-tert-butylphenol The 4-acetoxy-3,5-di-tert-butylanisole obtained in Example 13 and 1.37 kg (9.14 mol) of sodium iodide were dissolved in 5.0 L of acetonitrile; thereafter, 1.16 L (9.14 mol) of trimethylsilyl chloride was added dropwise and the mixture was refluxed for 8 hours. Thereafter, the reaction mixture was cooled to room temperature, water was added and the organic layer was separated. The organic layer was washed with an aqueous solution of sodium thiosulfate and aqueous sodium chloride in that order and dried over anhydrous sodium sulfate. The crude product obtained by concentrating the organic layer was recrystallized from an ethanol/water mixed solvent and the crystal was dried to give 1.55 kg of the title compound (92.4% in yield from the 2,6-di-tert-butyl-4-methoxyphenol of Example 13). ¹H NMR (270MHz, CDCl₃) δ ppm: 1.31(s,18H), 2.33(s,3H), 4.88(s,1H), 6.76(s,2H)

References:

US2003/204100,2003,A1 Location in patent:Page/Page column 14

1,4-Benzenediol, 2,6-bis(1,1-dimethylethyl)-, 1,4-diacetate

739-92-4
0 suppliers
inquiry

32102-41-3
11 suppliers
inquiry

References

489-01-0
88 suppliers
$45.00/1g

32102-41-3
11 suppliers
inquiry

References